MK-677, also known as Ibutamoren, promotes the production of growth hormone (GH) & increases insulin-like growth factor (IGF-1). Ibutamoren mimics the action of hormone ghrelin in the brain and binds to one of the GHSRs (GHSR) within the brain. This increases growth hormone levels.

Activated GHSR stimulates brain growth hormone release. Clinical studies have only shown that ibutamoren can increase appetite. The brain regions responsible for appetite, pleasure, mood and cognition are home to GHSR.

These functions may be affected by ibutamoren. It raises growth hormone levels, but not cortisol or other hormones. Cortisol can suppress the immune system, decrease wound healing, impair learning and memory. It’s generally not a good idea to have this hormone raised.


MK-677 has many benefits, including muscle building, muscle wasting reduction, increased bone density and anti-aging properties. It can also be helpful in the treatment of growth hormone deficiencies and may have nootropic properties. These benefits are more fully explained in the following article.

Helps to Build Muscles

Ibutamoren is often used to increase body mass and as an anabolic drug. It can be taken orally once daily. MK-677 increases Growth Hormone, IGF-1 and helps maintain lean body mass. Many believe Growth Hormone stimulates an increase in strength and muscle size. MK-677’s ability to increase Growth Hormone levels makes it a popular choice.

A study of 60-year-olds found that injections of Growth Hormones resulted in increased strength and endurance in the thighs. The results of MK-677 stimulating muscular growth will differ from person to person, depending on how they exercise and their health.

Another study of 24 obese men showed that ibutamoren treatment for two months increased lean mass and temporarily increased basal metabolic rates (BMR).

Reduces Muscle Wasting

Recent studies have shown that MK-677 can reduce muscle wasting due to a decrease in protein in a person’s diet. One study showed that MK-677 can reverse protein catabolism in healthy young adults. MK-677 could be a treatment option for people suffering from catabolic conditions.

Increases Bone Mass

Numerous studies have shown that MK-677 long-term can be very effective in increasing bone mineral density. This can be beneficial to many populations, including older adults, women with menopause, and obese people. Low bone mineral density can lead to health issues in these populations. MK-677 has been proven to be an effective treatment.

Ibutamoren was found to increase bone turnover in 24 healthy, obese male volunteers.

Ibutamoren was found to increase bone building in 187 older adults (65+) according to osteocalcin, which is a marker for bone turnover in multiple studies.

One study of 292 women postmenopausal found that ibutamoren improved bone mineral density. This helps to increase bone strength and prevent osteoporosis.

People who are eligible to receive MK-677’s ability increase bone density should research any potential side effects. Typically, it takes more than one year to see an increase in bone density.

Enhances Sleep

Because Growth Hormone has been shown to improve sleep quality, Ibutamoren Mesylate is often thought to be able to aid in improving sleep quality as it stimulates growth hormone production.

Study results showed that ibutamoren had a positive effect on sleep quality and duration in older and younger subjects.

There have been numerous reports of subjective improvements in the quality of sleep, which are not supported by scientific studies.

May Increase Longevity and Combat Aging

Like other hormones, Growth Hormone naturally starts to decline as we age. MK 677 can be beneficial for those who are aged as Growth Hormone (and IGF-1) will be increased in their bodies. MK 677 can help seniors with declining GH (Growth Hormone) levels.

A study of 65 older men and women found that daily ibutamoren had no adverse effects on GH or IGF-1 levels.

Another study of 24 obese men showed that ibutamoren improved the growth hormone profile.

May Have Nootropic Effects

MK-677 has many similarities to Ghrelin, and binds to its receptors. It is possible that MK 677 could have the same effect on the brain as Ghrelin.

There are not enough studies to prove that MK 677 has nootropic effects on brain. Scientists believe that MK 677 may be able to aid cognitive function through indirect means. One promising method is Ibutamoren’s ability increase REM sleep to improve sleep quality.

It is vital to get the right amount of sleep every night in order to maintain a healthy cognitive function. MK-677 is a supplement that can help improve cognitive function. MK-677’s ability to stimulate IGF-1 can indirectly improve cognitive function, based on IGF-1’s role in cognitive function. One study found that IGF-1 had a positive effect on participants’ performance in cognitive tests. Good cognitive function is dependent on good sleep.

Useful in Treatment of Growth Hormone Deficiency

Ibutamoren can be used to increase the levels of growth hormone, IGF-1 and IGFBP-3 in children who have a growth hormone deficiency. These effects can be achieved without altering the concentrations prolactin (T3), glucose (T4), thyroxine, cortisol, insulin, or triiodothyronine.

Ibutamoren was found to increase growth hormone and IGF-1 in severely GH-deficient males. There were no significant changes in thyroid hormone, cortisol, PRL or cortisol levels. However, glucose and insulin were both increased.


MK 677 does not have many side effects that users should be concerned about. However, certain populations might experience side effects.

MK-677 may pose a risk to individuals who are diabetic or have insulin sensitivity. MK-677 could exacerbate symptoms. MK-677 should be used in the right dosage. The dosage was crucial in studies that examined how MK-677 increased muscle mass. MK-677 side effects are often due to two things: prolonged use and improper dosage.

Most side effects reported by MK-677 are due to unnaturally high levels growth hormone in the body. This can be caused by taking too much of it too often.

  • Appetite increases
  • Lethargy
  • If you have had previous medical conditions, or high hormone levels, joint pain may occur.
  • Insulin resistance
  • Potential increase in prolactin levels that can be controlled

MK-677’s side effects are negligible if taken as directed.


MK-677 has been shown to have many health benefits for people with certain conditions. MK-677 can be very beneficial for those with low bone density, people who have difficulty sleeping at night, as well as individuals suffering from catabolic conditions.

MK 677’s ability to secrete Growth Hormone as well as IGF-1 effectively proves to be an effective tool for many populations. Numerous studies have shown MK 677 to be beneficial for the elderly, people with low bone density and those who have trouble sleeping. These populations can benefit from MK 677 as a tool to address issues caused by a deficiency of Growth Hormone or IGF-1.

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